Aspartic Hydroxamate Resistance and Asparaginase Regulation in the Fungus Aspergillus nidulans
نویسندگان
چکیده
منابع مشابه
The regulation of nitrate reductase in the fungus Aspergillus nidulans.
Nitrate reductase induction by nitrate and repression by NH,+ has been studied extensively in the simple eukaryote Aspergillus nidulans (Pateman & Cove, 1967; Cove & Pateman, 1968). Wild-type cells grown on minimal medium, with 20m~-NaNO~ as the nitrogen source, rapidly lose nitrate reductase activity when transferred either to minimal medium without N (-N medium) or to minimal medium without C...
متن کاملMethylammonium resistance in Aspergillus nidulans.
Mutants of Aspergillus nidulans resistant to methylammonium toxicity are simultaneously derepressed in the presence of ammonium for apparently all ammonium-repressible activities. Enzyme assays directly demonstrate derepression of nitrate, nitrite, and hydroxylamine reductases, xanthine dehydrogenase, urate oxidase, and allantoinase, whereas in vivo tests show that ammonium and methylammonium r...
متن کاملAmmonium regulation in Aspergillus nidulans.
l-Glutamate uptake, thiourea uptake, and methylammonium uptake and the intracellular ammonium concentration were measured in wild-type and mutant cells of Aspergillus nidulans held in various concentrations of ammonium and urea. The levels of l-glutamate uptake, thiourea uptake, nitrate reductase, and hypoxanthine dehydrogenase activity are determined by the extracellular ammonium concentration...
متن کاملReducing the cost of resistance; experimental evolution in the filamentous fungus Aspergillus nidulans.
We have studied compensatory evolution in a fludioxonil resistant mutant of the filamentous fungus Aspergillus nidulans. In an evolution experiment lasting for 27 weeks (about 3000 cell cycles) 35 parallel strains of this mutant evolved in three different environmental conditions. Our results show a severe cost of resistance (56%) in the absence of fludioxonil and in all conditions the mutant s...
متن کاملMitotic Recombination Accelerates Adaptation in the Fungus Aspergillus nidulans
Understanding the prevalence of sexual reproduction in eukaryotes is a hard problem. At least two aspects still defy a fully satisfactory explanation, the functional significance of genetic recombination and the great variation among taxa in the relative lengths of the haploid and diploid phases in the sexual cycle. We have performed an experimental study to explore the specific advantages of h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Microbiology
سال: 1977
ISSN: 0022-1287
DOI: 10.1099/00221287-98-2-493